Yes, not a problem. You can replace product imagery without altering the way your products are printed.
However, product photography can’t currently be replaced using the Shopify app itself. You’ll need to manually add or replace images in the Products section of your Shopify account.
If you’re replacing the product imagery completely, make sure you pair the right photo with the right product variant to avoid confusion further down the line. (You’d be surprised at how many people have accidentally mixed up the colours!)